For those who’ve began to consider longevity or perimenopause and that’s taken you down a rabbit gap of dietary supplements, I really feel you. AgelessRX got here on my radar in 2024 after a deep dive on researching LDN. As a result of I used to be able to preserve coaching, however my physique felt totally different and I wanted to determine the way to assist it.
As a result of most runners I work with aren’t in search of shortcuts. They’re already doing the issues:
- coaching persistently
- dialing in diet
- prioritizing sleep (or not less than attempting to)
And but… typically one thing nonetheless feels off.
Power dips. Restoration lags. That underlying “blah” feeling that’s laborious to clarify, however very actual. I used to be discovering this not simply in myself, however in so lots of our runners over 40 that I needed to discover choices. The complement market has an possibility for every little thing, however once more I needed one thing with a bit extra proof behind it and I used to be open to being the guinea pig for the group.
I’m so glad I used to be.
What’s AgelessRX?
An especially necessary distinction, AgelessRx isn’t a complement firm. It’s a telehealth platform.
Which means every little thing is overseen by U.S.-licensed physicians, it’s HIPAA-compliant, and so they work with compounding pharmacy companions to offer remedies which can be usually more durable to entry by way of a standard physician’s workplace.
The aim is absolutely about making longevity-focused care extra accessible and personalised.
For those who resolve to discover it, you’re not simply clicking “add to cart.” There’s a screening course of to find out if one thing is suitable for you, and ongoing check-ins to assist handle dosing alongside the way in which.
They provide a variety of choices—issues like NAD+, LDN, Metformin, GLP-1s, Sermorelin, Rapamycin, B12, and extra. I can’t converse to all of these, and I gained’t faux to. However I can share my expertise with LDN and NAD+, that are those I’ve hung out researching and testing myself.
And the explanation I even went down this path comes again to what I’m seeing on daily basis as a coach.
At this level, over 60% of our one-on-one athletes are girls navigating perimenopause or menopause (and sure, loads of males over 40, too). Which implies we’ve had a front-row seat to how shifting hormones can present up otherwise for everybody.
However there are positively patterns.
The commonest issues we hear?
Persistent, random aches.
Sleep disruptions.
And that underlying fatigue that doesn’t fairly match the trouble you’re placing in.
Which lead me to have a look at what can I do past good coaching to higher assist my altering physique (and my athletes!).
How Does it Work
- On-line consumption type / medical questionnaire
- Doctor opinions and approves (or declines) your prescription
- Remedy ships on to your door from a compounding pharmacy.
- I’ve had no points with pausing after I didn’t want and located it tremendous simple to cancel one subscription after I determined it wasn’t the best time for me.
- Word: some states require a video seek the advice of first
- ID verification required
- Subscription based mostly!! That is the one odd criticism from individuals, nevertheless it’s clearly marked it auto renews and as famous I discovered it tremendous simple to show off all on my own with out calling or utilizing on-line assist.
Low Dose Naltraxone for Aches, Cravings and Mind Fog
Low Dose Naltrexone (LDN) is a a lot smaller dose of a medicine initially utilized in greater doses for different medical situations.
At low doses (usually ~1–4.5 mg), it seems to work otherwise, primarily by:
- supporting the physique’s endorphin manufacturing
- modulating the immune system
- serving to scale back irritation
That is the place it will get fascinating for runners.
As a result of once we discuss feeling higher, operating stronger, and recovering nicely… we’re actually speaking about these precise methods.
After I entered perimenopause I went from being an athlete who not often had accidents or greater than somewhat twinge right here an there to somebody with random aches on a regular basis. I felt snug beginning hormone alternative remedy and that made a distinction in assuaging the unexplained accidents, however there was nonetheless aches that made no sense.
I did a ton of analysis on LDN and felt like AgelessRX was a dependable place to try it out.
LDN continues to be an rising space of analysis, however there are some promising research, notably round irritation, ache, and immune response.
- A research on fibromyalgia discovered that LDN lowered ache and improved temper in members
- Analysis printed in Medical Rheumatology confirmed enhancements in signs for individuals with Crohn’s illness and different inflammatory situations
- A evaluate in Frontiers in Immunology highlighted LDN’s potential position in regulating the immune system and decreasing persistent irritation
Whereas these aren’t operating particular research, they level to one thing related: when irritation and immune perform enhance, individuals are inclined to really feel higher general.
And while you really feel higher… you practice higher.
What have been my outcomes?
Some I anticipated and a few I didn’t, however all have been sufficient that I quietly advisable it to shut buddies over the subsequent 12 months and noticed lots of them have large adjustments too.
The factor to recollect is these aren’t instantaneous in a single day magic outcomes. This isn’t a ache killer, however it’s one thing that for me made a big change in my general feeling.
- Decreased the persistent irritation, so my random ankle ache or sudden neck ache stopped
- Decreased sugar cravings which was tremendous useful as we don’t course of sugar as nicely with perimenopause
- Improved sleep
- My temper additionally felt elevated
Pals with autoimmune points discovered their physique felt higher and one other with ADHD even discovered it helped them with the mind fog. I’m not calling it a remedy all or a miracle drug. All of us are nonetheless practising good sleep hygiene, hydrating, fueling and understanding.
However it felt prefer it was making these items simpler once more.
NAD+ for Power and Mind Fog
After I first began sharing about HRT, one of the vital fascinating responses I bought was from girls who stated, “I’m not prepared for that but… however I attempted NAD+ and felt superb.”
Power. Temper. Psychological readability.
It saved developing time and again.
So like with LDN, I made a decision to remain open to a brand new concept and take a look at it myself.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in each cell in your physique, and it performs a central position in how we produce vitality on the mobile degree—particularly contained in the mitochondria, that are basically the engines driving every little thing out of your exercises to your restoration. Analysis exhibits that NAD+ ranges decline as we age, and that drop is tied to adjustments in mitochondrial perform, metabolism, and general mobile well being.
That’s a giant a part of why it’s getting a lot consideration within the longevity house.
There’s additionally rising analysis taking a look at how supporting NAD+ ranges could affect ageing pathways, irritation, and muscle perform. For instance, a latest paper in Biochemical and Biophysical Analysis Communications explores how NAD+ precursors might play a job in age-related illnesses by supporting mobile restore processes and vitality metabolism.
And in additional utilized physiology, research have proven that restoring NAD+ ranges in ageing muscle can enhance mitochondrial perform, scale back oxidative stress, and even improve endurance and restoration in preclinical fashions.
So when individuals say they “really feel higher,” there’s not less than a physiological speculation behind it.
I attempted NAD+ as a nasal spray after listening to all these constructive experiences. And for me? It was… wonderful.
Not dangerous, not life-changing. I didn’t discover a dramatic shift in vitality or restoration, and in the end determined it wasn’t one thing I needed to maintain investing in long-term. The upside: it was simple to strive, and simply as simple to cease.
Ought to You Attempt LDN or NAD+?
And I feel that final level is a very necessary a part of this dialog.
As a result of whereas the science is promising, it’s nonetheless evolving. Loads of the strongest information is just not in runners navigating real-life coaching, stress, sleep, and hormones abruptly.
However that doesn’t imply it’s not value exploring.
It simply means we strategy it the identical means we strategy coaching: with curiosity, context, and a willingness to regulate.
For some, they is likely to be a significant lever for vitality and restoration. For others, it is likely to be impartial.
We’re on the cusp of a time the place all of the sudden ageing, perimenopause and menopause are being studied, mentioned extra brazenly and considered with options. BUT we don’t have all of the solutions but and I can completely say that the expertise varies by particular person.
So I’m simply hopeful that by sharing extra and speaking about it, I give others info I want I’d had on day one in all realizing one thing is totally different and never realizing the way to resolve it.
This isn’t a sponsored evaluate, however my expertise with LDN was so good that after a 12 months I reached out to AgelessRX.com as a result of I actually needed to share. They have been variety sufficient to offer a reduction code for 10% any first buy.
Ageless RX Low cost Code: RUNTOTHEFINISH
Personally I belief them and have appreciated all of the communication and repair that not simply I’ve obtained, however what I’ve seen in buddies who’ve tried it.
